THC Analog Suppresses Pain, Bladder Over-Activity From Interstitial Cystitis, Study S

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Oct 22, 2005
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Atlanta, GA: Administration of a synthetic, structural derivative of THC reduces bladder inflammation and bladder over-activity in animals, according to preclinical findings presented this week at the annual meeting of the American Urological Association.

Rats administered the THC analog IP 751 experienced reduced irritation and pain in the bladder associated with interstitial cystitis (IC), investigators reported. Interstitial cystitis is a chronic pelvic pain disorder that affects an estimated 700,000 Americans, mostly women.

Previous preclinical research has demonstrated cannabinoids and the endocannabinoid system to play a potential role in the treatment of various gastrointestinal disorders, such as Crohn's Disease and colitis, while clinical trials of natural cannabis extracts have demonstrated cannabis to dramatically reduce incontinence associated with Multiple Sclerosis.

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