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CBD extraction/FRACTIONATING THE PHYTOCANNABINOIDS BY THEIR VAPORIZATION POINTS

Discussion in 'Medical Marijuana' started by 7greeneyes, Mar 26, 2014.

  1. May 23, 2014 #21

    greenfriend

    greenfriend

    greenfriend

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    Citations: any organic chemistry textbook in the world. That article was obviously not written by someone who has taken organic chemistry.

    There are a number of organic (and inorganic) solvents that will extract the chemicals in cannabis. Different solvents will produce different chemical profiles (ex. the difference between butane and CO2 extractions). There are thousands of peer-reviewed journal articles detailing organic extraction methods, I am somewhat surprised that people haven't gone beyond the typical solvents currently in use.

    However, heat alone will simply decompose most of these compounds.
     
  2. May 24, 2014 #22

    7greeneyes

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    If you have links to any of these then please do. Do you have any?
     
  3. May 25, 2014 #23

    greenfriend

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    heres a couple links. provided that you have the equipment to remove all the solvent after the extraction the list of viable organic solvents goes on and on...chloroform, dichloromethane, diethyl ether, various alkanes, ethanol, light petroleum

    The overpressured layer chromatography method is of particular interest because it separates the cannabinoids effectively, allowing you to easily make a pure CBD extraction containing negligible THC

    hxxp://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1973.tb10609.x/pdf

    hxxp://www.sciencedirect.com/science/article/pii/S0021967301944814
     
  4. May 27, 2014 #24

    7greeneyes

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    thanks for those posting links. I'll have to review them. :)
     
  5. May 27, 2014 #25

    7greeneyes

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    That first link is just about solvent extraction of cannabinoids from 1972. Not isolation of CBD's.

    And that second link required me to join a science journal which I don't have time nor money to. You don't happen to have a membership there where you could repost here do you? That'd be awesome.
     
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  6. May 27, 2014 #26

    greenfriend

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    Solvent extractions can be used to extract all cannabinoids, but also to separate individual cannabinoids. Liquid-liquid extraction using a proper phase transfer catalyst can separate CBD from THC and other cannabinoids.

    Just because the article is old doesn't mean the info isn't still useful today, the basic principles of organic chemistry haven't changed in decades.
     
  7. May 28, 2014 #27

    7greeneyes

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    But the thing you're missing is the fractionating. I already know solvent extraction, that's old hat to me. Tell me the complete process of cbd isolation. Can you or can you not tell me the step by step process?

    Like I stated before, I can't access the other link you posted.
     
  8. May 30, 2014 #28

    greenfriend

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    If solvent extraction is "old hat" to you then you would have understood my previous post. Solvent extraction IS fractionating.

    1) general extraction with organic solvent
    2) Liquid-liquid extraction: use a PTC to bring CBD into the aqueous phase; decant organic phase; wash aqueous phase; convert back to organic phase and dehydrate; reextract with organic solvent; remove solvent

    This is one fractionating method that is fairly low cost, others involve very expensive equipment (see: GWpharma--->production of Sativex)
     
  9. May 30, 2014 #29

    7greeneyes

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    right on. closer to an answer. :)

    When I meant "old hat" I mean I've been armchairing the extraction process because the process was taught to me step by step with what material at what concentrations.

    No need to get your dander up...lol...
     
  10. Nov 28, 2018 #30

    bluegrasser

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    Im curious if anyone here uses a separation process as mentioned in this old thread to isolate CBD ?
     

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