Myself, I wait to trim up the bottoms no sooner then a week into 12/12, up to 2 weeks into 12/12. I never touch em when they are veggin.
I have had no issues of plants diein' or 'morphs at all. Maybe just lucky, but I have been doing it this way for years.
The way I look at it is, I wait at least a week into 12/12, after the plant has really started to do it's "transition stretch". This gives some of the lower branches a chance to catch up to the mains. Some make it, some don't.
Now, when I go in and trim up, If a lower branch has made it to the tiop of the canopy, I will only trim up the lower Nodes on that branch, leaving the top. MAke sense? I don't just trim up every branch 6-12" up from the bottom. I will judge the branch if it has "potential".
If I need cuts, I do take what cuts I need from them NO later then 4 days into 12/12. And, with some strains, this is almost too late. I will always come back and really clean up the bottoms a week or so later.
So, interesting question, and I see alot of folks do this differently. I am just stating my experience. Whats funny, is I am going to trim up the bottoms today, and the room has been in 12/12 for 14 days.